Which fever reducer is better for infants?

Sep 18, 2025 Source: Cainiu Health

Dr. Zhou Xiaofeng

Introduction

In general, when infants have a fever, an appropriate antipyretic should be selected under the guidance of a doctor. Common medications include acetaminophen suspension drops, acetaminophen granules, ibuprofen suspension, ibuprofen drops, and acetaminophen oral solution. It is also important to ensure adequate fluid intake for the infant, maintain good indoor ventilation, and avoid dressing the infant in excessive clothing, which may impair heat dissipation.

Under normal circumstances, when an infant has a fever, an appropriate antipyretic should be selected under the guidance of a doctor. Common medications include acetaminophen suspension drops, acetaminophen granules, ibuprofen suspension, ibuprofen drops, and acetaminophen oral solution. A detailed analysis is as follows:

1. Acetaminophen Suspension Drops

Acetaminophen suspension drops exert their antipyretic effect by inhibiting prostaglandin synthesis. They typically have a fruity flavor, which is generally well-accepted by infants. Suitable for infants aged 3 months and older, this medication provides mild fever reduction with minimal gastrointestinal irritation, making it one of the commonly used drugs for infants with low-grade fever.

2. Acetaminophen Granules

The active ingredient in acetaminophen granules is the same as that in the suspension drops, but in granule form, which must be dissolved in warm water before administration. Also suitable for infants aged 3 months and above, this formulation is rapidly absorbed and effectively reduces body temperature. It has relatively minor effects on liver and kidney function, making it ideal for infants who require rapid fever relief and do not mind the granule formulation.

3. Ibuprofen Suspension

Ibuprofen suspension works by inhibiting cyclooxygenase activity, thereby reducing prostaglandin production. It has a strong and long-lasting antipyretic effect. Suitable for infants aged 6 months and older, it not only reduces fever but also relieves mild pain associated with fever, such as headache and joint pain. However, it may irritate the gastrointestinal tract; therefore, it is recommended to administer with or after meals.

4. Ibuprofen Drops

Ibuprofen drops come in a liquid drop formulation, allowing precise dosing and easy adjustment based on the infant’s weight. The recommended age is the same as for ibuprofen suspension—infants aged 6 months and older. It acts quickly to reduce fever and is particularly suitable for younger infants with weak swallowing ability or those requiring strict dose control. Care should be taken to avoid concurrent use with other medications containing ibuprofen.

5. Acetaminophen Oral Solution

Acetaminophen oral solution is a liquid formulation that is easy for infants to swallow, with stable drug composition. Suitable for infants aged 3 months and older, it provides steady antipyretic effects with few side effects, making it appropriate for infants with sensitive gastrointestinal systems. The concentration should be carefully checked before administration to prevent dosing errors due to variations in concentration.

In daily care, ensure adequate fluid intake for the infant, maintain good indoor ventilation, and avoid overdressing the infant, which may impair heat dissipation. If the infant's fever persists or is accompanied by other abnormal symptoms, prompt medical attention is necessary.

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