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What are the side effects of Sertraline Hydrochloride Tablets?

Nov 17, 2025 Source: Cainiu Health
Dr. Zhang Baohua
Introduction
As a commonly used antidepressant, sertraline hydrochloride tablets may cause various side effects during treatment, mainly including gastrointestinal reactions, neurological symptoms, sexual dysfunction, metabolic and weight changes, mood fluctuations, etc. The manifestation of side effects varies among individuals, and not all users will experience them. Patients should strictly follow medical instructions when taking the medication and must not discontinue or adjust the dosage on their own.

Sertraline hydrochloride tablets, as a commonly used antidepressant, may cause various side effects during treatment, mainly including gastrointestinal reactions, neurological symptoms, sexual function disturbances, metabolic and weight changes, mood fluctuations, etc. A detailed analysis is as follows:

1. Gastrointestinal reactions: These are the most common during the initial phase of medication use, manifesting as nausea, vomiting, dry mouth, diarrhea, or constipation, with some patients experiencing loss of appetite. These symptoms are usually mild and tend to gradually subside within 1–2 weeks as the body adapts. Taking the medication after meals can help reduce discomfort.

2. Neurological symptoms: Dizziness, headache, and drowsiness frequently occur. Some patients may experience tremors, insomnia, or fatigue, while a few might have difficulty concentrating or temporary memory decline. These symptoms are often related to the drug's modulation of neurotransmitters and generally do not interfere with daily functioning.

3. Sexual function impact: Some patients may develop reduced libido, delayed ejaculation, or anorgasmia. This type of side effect can significantly affect quality of life. Most individuals recover gradually after discontinuation, but any such issues should be promptly discussed with a physician.

4. Metabolic and weight changes: A minority of patients may experience weight gain, possibly due to improved appetite or slight metabolic alterations; weight loss is occasionally reported and typically does not involve malnutrition. Regular weight monitoring combined with dietary adjustments can effectively manage these changes.

5. Mood fluctuations: Anxiety and irritability may emerge initially, and in rare cases, depressive symptoms may worsen. Additionally, increased sweating—usually mild and localized—may occur, which generally requires no special intervention.

Side effects vary significantly among individuals, and not all users will experience them. Patients should strictly follow medical instructions and must not discontinue or adjust their dosage without consultation. Maintaining regular sleep patterns and a balanced diet can help alleviate discomfort caused by medication side effects.

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