Can I smoke while taking Pu'an Le tablets?

Dec 08, 2025 Source: Cainiu Health

Dr. Ren Yi

Introduction

Smoking releases harmful substances such as nicotine, causing vasoconstriction and increased heart rate, which directly counteracts the effects of nifedipine controlled-release tablets in dilating blood vessels and lowering blood pressure. This makes it difficult to maintain stable blood pressure control, potentially leading to fluctuations and elevated blood pressure, thereby increasing the risk of hypertension-related complications. Meanwhile, these harmful substances damage vascular endothelium and accelerate the progression of atherosclerosis, completely opposing the goals of drug therapy.

The generic name of Pu'anle Tablets is Nifedipine Controlled-release Tablets. Generally, smoking is not recommended while taking nifedipine controlled-release tablets, as smoking may interfere with the drug's effectiveness and worsen the condition. There are no circumstances in which smoking is considered safe or appropriate. If you have any concerns, it is advisable to consult a healthcare professional in advance. Detailed explanations are as follows:

Smoking releases harmful substances such as nicotine, which can cause blood vessel constriction and increased heart rate. This directly counteracts the vasodilatory and blood pressure-lowering effects of nifedipine controlled-release tablets, making it difficult to maintain stable blood pressure control. It may even lead to blood pressure fluctuations and elevation, increasing the risk of hypertension-related complications. Meanwhile, these harmful substances damage vascular endothelial cells and accelerate the progression of atherosclerosis, which runs completely contrary to the goals of drug therapy.

Even minimal smoking can affect the liver's efficiency in metabolizing the medication, reducing the effective drug concentration in the body. This may necessitate higher doses to achieve the desired antihypertensive effect, thereby indirectly increasing the likelihood of adverse drug reactions. Long-term smoking also increases the burden on the heart and raises the risk of serious cardiovascular and cerebrovascular events such as myocardial ischemia and cerebral infarction.

Strict smoking cessation is required during treatment with nifedipine controlled-release tablets, along with avoiding exposure to secondhand and thirdhand smoke. Patients should adhere to prescribed dosing regimens and must not adjust their dosage independently due to blood pressure changes after smoking. Regular blood pressure monitoring is essential; if fluctuations occur or symptoms such as dizziness or chest tightness develop, prompt medical consultation is necessary to adjust the treatment plan and ensure effective blood pressure control and overall health protection.

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