What is serum human chorionic gonadotropin (hCG)?

May 14, 2022 Source: Cainiu Health
Dr. Chen Zhe
Introduction
Serum human chorionic gonadotropin (hCG) prolongs the lifespan of the menstrual corpus luteum, causing it to enlarge and transform into the corpus luteum of pregnancy. It stimulates the conversion of androgens to estrogens and promotes progesterone synthesis. Additionally, hCG binds to the surface of trophoblastic cells, protecting embryonic trophoblasts from attack by maternal lymphocytes. Human chorionic gonadotropin (hCG), a glycoprotein, is secreted by the trophoblastic cells of the placenta.

Human chorionic gonadotropin (hCG) is a glycoprotein secreted by the trophoblastic cells of the placenta and possesses both follicle-stimulating hormone (FSH)-like and luteinizing hormone (LH)-like activities. Then, what exactly is serum human chorionic gonadotropin?

What Is Serum Human Chorionic Gonadotropin?

Serum human chorionic gonadotropin (hCG) prolongs the lifespan of the menstrual corpus luteum, causing it to enlarge and transform into the corpus luteum of pregnancy (pregnancy corpus luteum). It stimulates the conversion of androgens into estrogens and promotes progesterone synthesis. Additionally, hCG binds to the surface of trophoblastic cells, thereby protecting embryonic trophoblasts from attack by maternal lymphocytes. Furthermore, hCG exhibits LH-like activity and can bind to thyroid-stimulating hormone (TSH) receptors on maternal thyroid cells, thereby stimulating thyroid activity.

Human chorionic gonadotropin (hCG), commonly abbreviated as hCG, is a glycoprotein secreted by the trophoblastic cells of the placenta. After fertilization in females, the ovum migrates to the uterine cavity and implants, forming an embryo. As the embryo develops into a fetus, syncytiotrophoblast cells of the placenta produce large amounts of hCG, which enters the maternal bloodstream and is subsequently excreted into the urine. Serum and urinary hCG levels begin rising rapidly within 1–2.5 weeks after conception, peak at approximately 8 weeks of gestation, decline to moderate levels starting in the fourth month of pregnancy, and remain stable at this level until term.

The primary physiological functions of human chorionic gonadotropin include ensuring adequate blood supply, nutrition, and metabolic support for the embryo and fetus; protecting the embryo from maternal immune rejection; promoting follicular maturation; and maintaining pregnancy. We hope this explanation has been helpful. Wishing you good health and happiness!

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