Normal value of sex hormone-binding globulin
Disease description:
When I was undergoing the six hormone tests, an abnormality was detected in the sex hormone-binding globulin (SHBG) test. What is the normal value for sex hormone-binding globulin?
Doctor's answer (1)
Dr. Liu Feng
Sex hormone-binding globulin (SHBG) is a protein primarily synthesized in the liver. It binds to sex hormones such as testosterone and estradiol in the bloodstream, regulating their bioavailability. Changes in SHBG levels can reflect the endocrine status of the body and have significant clinical importance in assessing gonadal function, androgen resistance, obesity, diabetes, and certain tumor diseases.
The normal reference range varies depending on gender and physiological status. Specifically:
1. Men: The normal SHBG range is approximately 10–80 nmol/L.
2. Women: The normal SHBG range is broader, generally between 26.1–100 nmol/L.
Fluctuations in these values may be related to physiological conditions such as the menstrual cycle, pregnancy, and menopause. Abnormal SHBG levels may indicate endocrine disorders, liver disease, or other conditions, and medical consultation is recommended.
