What disease is atypical lymphoid cells?

Feb 21, 2023 Source: Cainiu Health
Dr. Li Qing
Introduction
The presence of atypical lymphocytes may be associated with conditions such as infectious mononucleosis, neutropenia, brucellosis, systemic lupus erythematosus, or lymphocytic leukemia. To confirm a specific diagnosis, clinical evaluation combined with other laboratory tests is usually required. If atypical lymphocytes are detected, it is recommended to consult a physician.

The presence of atypical lymphocytes may be associated with conditions such as infectious mononucleosis, neutropenia, brucellosis, systemic lupus erythematosus, and lymphocytic leukemia. A detailed analysis is as follows:

1. Infectious Mononucleosis

Infectious mononucleosis is a proliferative infectious disease caused by the Epstein-Barr (EB) virus, characterized by benign proliferation of lymphocytes. After one episode of the illness, individuals usually develop long-lasting immunity, making reinfection rare. The EB virus is primarily transmitted through close oral contact, such as kissing, sharing eating utensils, or pre-chewing food for infants. It can also spread via respiratory droplets and, occasionally, through blood transfusion. This condition requires medical diagnosis and symptomatic management under a physician's guidance.

2. Neutropenia

During viral infections such as influenza virus, rubella virus, or hepatitis virus infection, a decrease in neutrophil count accompanied by a relative increase in lymphocyte proportion may occur. This imbalance typically improves significantly once the infection is controlled.

3. Brucellosis

Brucellosis is a zoonotic systemic infectious disease caused by Brucella bacteria. It can be transmitted through the digestive tract, skin or mucous membrane contact, and the respiratory tract. Patients may present with various symptoms, including damage to the muscular, joint, nervous, urogenital, and cardiovascular systems. Common manifestations include fever, joint pain, muscle aches, and fatigue. Laboratory tests often reveal a marked increase in atypical lymphocytes.

4. Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disorder that may lead to abnormal immune system activation, resulting in the appearance of atypical lymphocytes.

5. Lymphocytic Leukemia

Lymphocytic leukemia is a hematologic malignancy characterized by uncontrolled proliferation of lymphocytes. In this condition, atypical lymphocytes may appear in the bloodstream.

To confirm a specific diagnosis, clinical evaluation combined with additional laboratory tests is typically required. If atypical lymphocytes are detected, it is recommended to consult a physician for professional advice and further diagnostic assessment.


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