How many doses of the hepatitis B booster vaccine are required?

Jul 18, 2025 Source: Cainiu Health

Dr. Shen Yonghua

Introduction

When the hepatitis B surface antibody titer in the body drops significantly to below 10 mIU/mL, administering a single booster dose can stimulate the immune system to produce more antibodies, rapidly increasing the antibody titer and thereby maintaining effective protection against the hepatitis B virus. This situation represents a commonly encountered clinical indication for vaccination. After receiving a hepatitis B vaccine booster, individuals should remain at the vaccination site for 30 minutes of observation before leaving.

Generally speaking, a hepatitis B booster shot refers to an additional dose of the hepatitis B vaccine. Usually, only one booster shot is required. If there are any concerns, it is recommended to seek medical advice in advance. Detailed explanations are as follows:

If the level of hepatitis B surface antibodies in the body has significantly decreased, to below 10 mIU/mL, receiving one booster dose can stimulate the immune system to produce more antibodies, rapidly increasing antibody levels and thereby maintaining effective protection against the hepatitis B virus. This situation is relatively common in clinical practice.

For certain special populations, such as healthcare workers who frequently come into contact with hepatitis B patients or individuals with weakened immune function, even if their antibody levels are at or above 10 mIU/mL, they may still choose to receive one booster dose to ensure stable immune protection and further strengthen the protective effect.

After receiving a hepatitis B vaccine booster shot, individuals should remain at the vaccination site for approximately 30 minutes of observation before leaving.

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